An honor meeting the Godfather of Mesenchymal Stem Cell, Dr. Arnold Caplan. Blessed to have spent an evening with a fellow alumni of Johns Hopkins.

How stem cells differ from exosomes?

Exosomes are small signaling proteins that are derived from cells. The ones used in regenerative therapies come directly from stem cells, so even though they are not stem cells, exosomes contain much of the important signaling pathways found in stem cells.

Why exosomes are important?

Exosomes help to signal important information to cells that don’t communicate well with each other due to a decease process or normal aging.

How do exosomes work?

Exosomes carry genetic information, proteins and messenger RNA. Because of their unique shape and content, they are able to tell cells how and when to react.

Exosomes from young stem cells rejuvenate the older cells. They assist in calming an overactive immune system or modulating it to respond in a coordinated and thus more effective fashion.

Therapeutic Uses of Exosomes

Patients with degenerative diseases will benefit the most from exosome therapy. Lyme disease, chronic inflammation, autoimmune disease, and other chronic degenerative diseases are primary candidates for this treatment.

Stem cell-derived exosomes have anti-inflammatory potential. They induce high levels of anti-inflammatory cytokines, and therefore patients with autoimmune and inflammation disorders may respond to the benefits of exosome therapy.

What are the benefits of exosome therapy?

The benefits of exosome therapy vary, but mot patients report a reduction of the inflammatory symptoms of their chronic disease. This indicates the exosomes are assisting in the repair and regulation process. As time goes on, exosomes will also reprogram the cell function and aid in repair processes. It may take up to four-six months to see the full benefit, but they should last as long as 12 months.

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